Info
| ID | 6150 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | 4 |
| SMILES | O.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc(-c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)cc1 |
TUCAN
C28H16N4O3Re/(1-36)(2-21)(3-35)(4-19)(5-24)(6-20)(7-17)(8-23)(9-27)(10-25)(11-28)(12-29)(13-18)(14-26)(15-22)(16-46)(17-24)(17-31)(18-22)(18-36)(19-21)(19-34)(20-23)(20-32)(21-25)(22-30)(23-33)(24-35)(25-29)(26-29)(26-34)(27-28)(27-33)(28-32)(30-38)(30-40)(31-37)(31-39)(32-34)(33-41)(35-47)(36-45)(37-38)(37-48)(38-46)(39-40)(39-47)(40-45)(41-46)(41-48)(42-49)(43-50)(44-51)(47-52)(48-52)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 0.04 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 0.12 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»