Info
| ID | 6148 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"O": 3, "N": 5} |
| Abbreviation | 2 |
| SMILES | O.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc2c(-c3nc4c5cccnc5c5ncccc5c4[nH]3)c[nH]c2c1 |
TUCAN
C24H13N5O3Re/(1-18)(2-17)(3-14)(4-20)(5-27)(6-21)(7-19)(8-15)(9-26)(10-16)(11-28)(12-40)(13-39)(14-18)(14-22)(15-16)(15-23)(16-28)(17-19)(17-31)(18-26)(19-21)(20-21)(20-25)(22-29)(22-30)(23-32)(23-33)(24-25)(24-27)(24-34)(25-31)(26-41)(27-40)(28-38)(29-32)(29-42)(30-33)(30-41)(31-40)(32-39)(33-38)(34-39)(34-42)(35-43)(36-44)(37-45)(41-46)(42-46)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 5 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 23 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»