Info
| ID | 6147 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 3} |
| Abbreviation | 1 |
| SMILES | COc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(OC)n1.O.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C23H15N5O5Re/(1-26)(2-17)(3-20)(4-36)(5-35)(6-36)(7-36)(8-35)(9-16)(10-25)(11-35)(12-21)(13-18)(14-19)(15-41)(16-17)(16-22)(17-25)(18-21)(18-23)(19-20)(19-24)(20-38)(21-26)(22-27)(22-28)(23-29)(23-30)(24-31)(24-37)(25-39)(26-43)(27-30)(27-39)(28-29)(28-41)(29-42)(30-43)(31-41)(31-42)(32-44)(33-45)(34-46)(35-47)(36-48)(37-40)(37-47)(38-40)(38-48)(42-49)(43-49)(47-49)(48-49)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RPE-1 | 0.36 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| PC-3 | 4.6 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»