Info
| ID | 6139 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 3} |
| Abbreviation | Re9 |
| SMILES | CCCCn1c(-c2nc3ccccc3s2)nc2cc(C(=O)OC)ccc21.CN(C)c1ccncc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C30H29N5O5ReS/(1-41)(2-35)(3-56)(4-31)(5-43)(6-39)(7-47)(8-41)(9-40)(10-32)(11-43)(12-45)(13-38)(14-56)(15-43)(16-44)(17-40)(18-47)(19-30)(20-30)(21-30)(22-37)(23-44)(24-56)(25-34)(26-46)(27-33)(28-36)(29-44)(30-41)(31-45)(31-48)(32-34)(32-58)(33-37)(33-49)(34-36)(35-42)(35-51)(36-38)(37-42)(38-50)(39-46)(39-48)(40-41)(40-47)(42-57)(43-60)(44-60)(45-62)(46-62)(47-61)(48-60)(49-51)(49-61)(50-58)(50-64)(51-63)(52-59)(52-61)(52-63)(53-65)(54-66)(55-68)(56-69)(57-67)(57-69)(58-70)(59-64)(59-70)(62-71)(63-71)(64-71)(69-71)(70-71)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.3 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 1.9 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 11 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»