Info
| ID | 6138 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 3} |
| Abbreviation | Re8 |
| SMILES | CCCCn1c(-c2ccc3ccccc3n2)nc2cc(C(=O)OC)ccc21.CN(C)c1ccncc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C32H31N5O5Re/(1-45)(2-62)(3-62)(4-50)(5-48)(6-35)(7-52)(8-62)(9-52)(10-44)(11-44)(12-34)(13-33)(14-43)(15-42)(16-48)(17-48)(18-36)(19-37)(20-32)(21-45)(22-32)(23-32)(24-38)(25-41)(26-39)(27-51)(28-40)(29-49)(30-49)(31-49)(32-45)(33-50)(33-53)(34-35)(34-46)(35-43)(36-37)(36-57)(37-46)(38-51)(38-53)(39-47)(39-55)(40-43)(40-54)(41-42)(41-56)(42-47)(44-45)(44-52)(46-54)(47-63)(48-65)(49-65)(50-66)(51-66)(52-64)(53-65)(54-67)(55-56)(55-68)(56-64)(57-58)(57-67)(58-64)(58-68)(59-69)(60-71)(61-72)(62-73)(63-70)(63-73)(66-74)(67-74)(68-74)(73-74)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.49 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 3.1 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 9 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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