Info
| ID | 6137 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 3} |
| Abbreviation | Re7 |
| SMILES | CCCCn1c(-c2ccccn2)nc2cc(C(=O)OC)ccc21.CN(C)c1ccncc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C28H29N5O5Re/(1-39)(2-56)(3-56)(4-44)(5-42)(6-38)(7-47)(8-34)(9-31)(10-46)(11-36)(12-42)(13-42)(14-47)(15-35)(16-30)(17-30)(18-30)(19-39)(20-40)(21-40)(22-32)(23-37)(24-56)(25-45)(26-33)(27-43)(28-43)(29-43)(30-40)(31-44)(31-48)(32-45)(32-48)(33-41)(33-49)(34-35)(34-50)(35-38)(36-37)(36-41)(37-51)(38-46)(39-40)(39-47)(41-57)(42-59)(43-59)(44-60)(45-60)(46-62)(47-58)(48-59)(49-51)(49-61)(50-52)(50-62)(51-58)(52-58)(52-61)(53-63)(54-65)(55-66)(56-67)(57-64)(57-67)(60-68)(61-68)(62-68)(67-68)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.92 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 9.1 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 49 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»