Info
| ID | 6136 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 3} |
| Abbreviation | Re6 |
| SMILES | CCCCn1c(-c2nc3ccccc3s2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccncc1 |
TUCAN
C28H24N4O5ReS/(1-33)(2-29)(3-49)(4-26)(5-32)(6-36)(7-25)(8-25)(9-41)(10-27)(11-49)(12-41)(13-31)(14-39)(15-40)(16-25)(17-36)(18-49)(19-34)(20-28)(21-37)(22-35)(23-30)(24-37)(25-37)(26-32)(26-43)(27-28)(27-39)(28-34)(29-31)(29-33)(30-31)(30-51)(32-38)(33-44)(34-40)(35-38)(35-42)(36-37)(36-41)(38-50)(39-54)(40-54)(41-53)(42-43)(42-55)(43-53)(44-51)(44-56)(45-52)(45-53)(45-55)(46-57)(47-58)(48-60)(49-61)(50-59)(50-61)(51-62)(52-56)(52-62)(54-63)(55-63)(56-63)(61-63)(62-63)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 1.2 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 5.4 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 23 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»