Info
| ID | 6135 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 3} |
| Abbreviation | Re5 |
| SMILES | CCCCn1c(-c2ccc3ccccc3n2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccncc1 |
TUCAN
C30H26N4O5Re/(1-38)(2-34)(3-55)(4-37)(5-41)(6-32)(7-41)(8-27)(9-27)(10-33)(11-35)(12-39)(13-31)(14-44)(15-28)(16-40)(17-46)(18-36)(19-45)(20-29)(21-30)(22-27)(23-46)(24-55)(25-55)(26-40)(27-41)(28-30)(28-44)(29-30)(29-45)(31-42)(31-48)(32-34)(32-50)(33-37)(33-49)(34-38)(35-36)(35-47)(36-42)(37-43)(38-39)(39-43)(40-41)(40-46)(42-56)(43-50)(44-60)(45-60)(46-57)(47-48)(47-57)(48-58)(49-51)(49-59)(50-59)(51-57)(51-58)(52-61)(53-63)(54-64)(55-65)(56-62)(56-65)(58-66)(59-66)(60-66)(65-66)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.89 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 4.2 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 10 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»