Info
| ID | 6134 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 3} |
| Abbreviation | Re4 |
| SMILES | CCCCn1c(-c2ccccn2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccncc1 |
TUCAN
C26H24N4O5Re/(1-25)(2-33)(3-40)(4-30)(5-34)(6-36)(7-41)(8-49)(9-31)(10-29)(11-38)(12-26)(13-36)(14-41)(15-32)(16-25)(17-39)(18-27)(19-28)(20-25)(21-35)(22-49)(23-49)(24-35)(25-36)(26-28)(26-38)(27-28)(27-39)(29-37)(29-42)(30-32)(30-37)(31-33)(31-34)(32-43)(33-40)(34-44)(35-36)(35-41)(37-50)(38-54)(39-54)(40-53)(41-51)(42-43)(42-52)(43-51)(44-45)(44-53)(45-51)(45-52)(46-55)(47-56)(48-57)(49-59)(50-58)(50-59)(52-60)(53-60)(54-60)(59-60)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 11 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | 17 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»