Info
| ID | 6133 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re3 |
| SMILES | CCCCn1c(-c2nc3ccccc3s2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-] |
TUCAN
C23H19N3O5ReS/(1-20)(2-20)(3-29)(4-39)(5-31)(6-39)(7-21)(8-31)(9-20)(10-39)(11-22)(12-28)(13-29)(14-27)(15-25)(16-28)(17-23)(18-24)(19-26)(20-29)(21-22)(21-32)(22-30)(23-24)(23-25)(24-26)(25-41)(26-33)(27-30)(27-34)(28-29)(28-31)(30-40)(31-43)(32-34)(32-43)(33-41)(33-45)(34-44)(35-42)(35-43)(35-44)(36-47)(37-48)(38-49)(39-50)(40-46)(40-50)(41-51)(42-45)(42-51)(44-52)(45-52)(50-52)(51-52)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 4.4 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| A2780 | 5.1 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | — | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»