Info
| ID | 6132 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re2 |
| SMILES | CCCCn1c(-c2ccc3ccccc3n2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-] |
TUCAN
C25H21N3O5Re/(1-33)(2-32)(3-36)(4-24)(5-26)(6-28)(7-22)(8-32)(9-22)(10-31)(11-23)(12-27)(13-33)(14-36)(15-45)(16-45)(17-22)(18-30)(19-45)(20-29)(21-25)(22-33)(23-24)(23-37)(24-35)(25-26)(25-38)(26-28)(27-28)(27-34)(29-35)(29-39)(30-31)(30-40)(31-34)(32-33)(32-36)(34-38)(35-46)(36-47)(37-39)(37-47)(38-48)(39-49)(40-41)(40-48)(41-47)(41-49)(42-51)(43-52)(44-53)(45-54)(46-50)(46-54)(48-55)(49-55)(54-55)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| A2780 | 5.1 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | — | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»