Info
| ID | 6131 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re1 |
| SMILES | CCCCn1c(-c2ccccn2)nc2cc(C(=O)OC)ccc21.[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-] |
TUCAN
C21H19N3O5Re/(1-28)(2-28)(3-31)(4-21)(5-23)(6-26)(7-20)(8-27)(9-22)(10-25)(11-20)(12-27)(13-39)(14-39)(15-20)(16-31)(17-39)(18-24)(19-30)(20-28)(21-22)(21-29)(22-32)(23-26)(23-30)(24-29)(24-33)(25-26)(25-34)(27-28)(27-31)(29-40)(30-43)(31-41)(32-33)(32-41)(33-42)(34-35)(34-43)(35-41)(35-42)(36-44)(37-46)(38-47)(39-48)(40-45)(40-48)(42-49)(43-49)(48-49)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 7.3 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| HeLa | 17 | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
| BGM | — | — | 10.1021/acs.jmedchem.3c01869 | 2024 |
🧬 Cell Death Types (1)
Pyroptosis
high
«Scanning electron microscopy (SEM) analysis uncovered notable alterations in the morphology of cells subjected to Re9 treatment. These changes were distinctly characterized by a fried egg-like appeara...»