Info
| ID | 6130 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 4, "O": 2} |
| Abbreviation | 2 |
| SMILES | Nc1nc(Nc2ccccc2)nc(-c2ccccn2)n1.[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-] |
TUCAN
C17H12N6O3Re/(1-14)(2-17)(3-20)(4-16)(5-15)(6-21)(7-13)(8-19)(9-18)(10-33)(11-30)(12-30)(13-14)(13-22)(14-15)(15-21)(16-17)(16-23)(17-20)(18-19)(18-20)(19-23)(21-32)(22-24)(22-32)(23-33)(24-31)(24-34)(25-30)(25-31)(25-35)(26-33)(26-34)(26-35)(27-36)(28-37)(29-38)(34-39)(35-39)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 31 | — | 10.1021/ic061518s | 2007 |
| KB-3-1 | 44 | — | 10.1021/ic061518s | 2007 |
| HeLa | 50 | — | 10.1021/ic061518s | 2007 |
| CCD-19Lu | 1.1e+02 | — | 10.1021/ic061518s | 2007 |
| KB-V1 | 2e+02 | — | 10.1021/ic061518s | 2007 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to confocal microscopic and flow cytometric studies, 1·(PF6)2 and 2 induced apoptosis (50−60%) in cancer cells with <5% necrosis detected.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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