Info
| ID | 6111 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir-NPX-2 |
| SMILES | COc1ccc2cc(C(C)C(=O)OCc3ccnc(-c4cc(COC(=O)C(C)c5ccc6cc(OC)ccc6c5)ccn4)c3)ccc2c1.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1 |
TUCAN
C58H48IrN4O6S2/(1-53)(2-103)(3-68)(4-70)(5-49)(6-58)(7-88)(8-63)(9-95)(10-55)(11-54)(12-76)(13-85)(14-49)(15-62)(16-104)(17-56)(18-87)(19-95)(20-64)(21-97)(22-86)(23-57)(24-95)(25-73)(26-71)(27-65)(28-49)(29-60)(30-59)(31-97)(32-69)(33-98)(34-50)(35-90)(36-96)(37-61)(38-67)(39-89)(40-50)(41-75)(42-98)(43-96)(44-96)(45-72)(46-50)(47-66)(48-74)(49-85)(50-86)(51-53)(51-105)(52-71)(52-106)(53-103)(54-55)(54-91)(55-68)(56-73)(56-92)(57-80)(57-88)(58-78)(58-82)(59-81)(59-90)(60-61)(60-78)(61-99)(62-63)(62-77)(63-82)(64-80)(64-93)(65-69)(65-84)(66-67)(66-79)(67-100)(68-87)(69-83)(70-77)(70-99)(71-104)(72-73)(72-89)(74-81)(74-94)(75-79)(75-83)(76-84)(76-100)(77-78)(79-84)(80-97)(81-98)(82-85)(83-86)(85-101)(86-102)(87-107)(88-109)(89-108)(90-110)(91-105)(91-107)(92-106)(92-108)(93-94)(93-109)(94-110)(95-113)(96-115)(97-114)(98-116)(99-113)(100-115)(101-111)(101-114)(102-112)(102-116)(103-117)(104-118)(105-117)(106-118)(107-119)(108-119)(109-119)(110-119)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 1.6 | — | 10.1039/d4dt00575a | 2024 |
| HeLa | 2.6 | — | 10.1039/d4dt00575a | 2024 |
| HepG2 | 3.2 | — | 10.1039/d4dt00575a | 2024 |
| A549 | 3.4 | — | 10.1039/d4dt00575a | 2024 |
| LO2 | 4.5 | — | 10.1039/d4dt00575a | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«induced apoptosis in A549R cells by damaging the structure and function of mitochondria»
Immunogenic Cell Death
high
«release of immunogenic cell death (ICD) related signaling molecules such as damage-associated molecular patterns (DAMPs) (cell surface calreticulin (CRT), high mobility group box 1 (HMGB1), and adenos...»