Info
| ID | 61 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru2 |
| SMILES | CC#N.CC#N.[c-]1n(-c2ccccn2)cc[n+]1Cc1ccccc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C29H27N7Ru/(1-31)(2-28)(3-28)(4-28)(5-33)(6-41)(7-34)(8-36)(9-50)(10-30)(11-47)(12-40)(13-52)(14-37)(15-42)(16-49)(17-29)(18-39)(19-51)(20-38)(21-32)(22-43)(23-52)(24-35)(25-48)(26-29)(27-29)(28-45)(29-46)(30-32)(30-36)(31-33)(31-53)(32-38)(33-34)(34-47)(35-41)(35-48)(36-44)(37-42)(37-43)(38-39)(39-44)(40-41)(40-54)(42-56)(43-51)(44-52)(45-57)(46-58)(47-62)(48-63)(49-50)(49-60)(50-59)(51-61)(52-60)(53-54)(53-62)(54-63)(55-59)(55-60)(56-59)(56-61)(61-64)(62-64)(63-64)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 30 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 95 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | — | — | 10.1002/chem.202002970 | 2020 |
| A2780 | — | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | — | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | — | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»