Info
| ID | 6097 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-pbt-Tz |
| SMILES | Cc1nnc(-c2ccc(-c3nc4c5cccnc5c5ncccc5c4n3-c3ccccc3)cc2)nn1.[c-]1ccccc1-c1nc2ccccc2s1.[c-]1ccccc1-c1nc2ccccc2s1 |
TUCAN
C54H34IrN10S2/(1-53)(2-51)(3-38)(4-47)(5-40)(6-64)(7-39)(8-62)(9-42)(10-60)(11-48)(12-45)(13-57)(14-73)(15-46)(16-59)(17-44)(18-35)(19-35)(20-49)(21-74)(22-50)(23-41)(24-58)(25-56)(26-43)(27-35)(28-55)(29-65)(30-61)(31-52)(32-63)(33-66)(34-54)(35-82)(36-38)(36-67)(37-44)(37-68)(38-59)(39-50)(39-67)(40-42)(40-85)(41-52)(41-68)(42-51)(43-54)(43-86)(44-61)(45-63)(45-73)(46-47)(46-71)(47-70)(48-64)(48-78)(49-55)(49-71)(50-59)(51-53)(52-61)(53-80)(54-62)(55-70)(56-64)(56-66)(57-65)(57-72)(58-66)(58-78)(60-62)(60-81)(63-69)(65-74)(67-87)(68-88)(69-75)(69-79)(70-83)(71-84)(72-76)(72-77)(73-89)(74-90)(75-77)(75-92)(76-79)(76-90)(77-91)(78-92)(79-89)(80-85)(80-95)(81-86)(81-96)(82-94)(82-97)(83-93)(83-98)(84-91)(84-92)(85-99)(86-100)(87-95)(87-99)(88-96)(88-100)(93-94)(95-101)(96-101)(97-98)(97-101)(98-101)(99-101)(100-101)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.4 | 0.043 | 10.1039/d4dt01665c | 2024 |
| MDA-MB-231 | 8.1 | 0.052 | 10.1039/d4dt01665c | 2024 |
| A549 | 8.4 | 0.024 | 10.1039/d4dt01665c | 2024 |
| HLF | 17 | 0.014 | 10.1039/d4dt01665c | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«When receiving a low-dose one- or two-photon PDT, they become highly potent towards A549 lung cancer cells (with IC50 values ranging from 24.0 nM to 96.0 nM) through the generation of reactive oxygen ...»