Info
| ID | 6096 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir-ppy-Tz |
| SMILES | Cc1nnc(-c2ccc(-c3nc4c5cccnc5c5ncccc5c4n3-c3ccccc3)cc2)nn1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C50H34IrN10/(1-39)(2-71)(3-46)(4-56)(5-45)(6-40)(7-44)(8-51)(9-41)(10-38)(11-52)(12-42)(13-43)(14-49)(15-58)(16-72)(17-54)(18-61)(19-47)(20-35)(21-35)(22-64)(23-73)(24-57)(25-53)(26-74)(27-60)(28-35)(29-59)(30-62)(31-63)(32-50)(33-55)(34-48)(35-82)(36-40)(36-66)(37-44)(37-67)(38-39)(38-41)(39-71)(40-42)(41-75)(42-45)(43-44)(43-47)(45-46)(46-66)(47-61)(48-60)(48-80)(49-50)(49-72)(50-65)(51-52)(51-57)(52-78)(53-63)(53-78)(54-56)(54-69)(55-60)(55-74)(56-68)(57-63)(58-62)(58-70)(59-64)(59-68)(61-67)(62-73)(64-69)(65-79)(65-81)(66-75)(67-80)(68-83)(69-84)(70-76)(70-77)(71-91)(72-85)(73-86)(74-92)(75-91)(76-79)(76-86)(77-81)(77-87)(78-88)(79-85)(80-92)(81-88)(82-90)(82-93)(83-89)(83-94)(84-87)(84-88)(89-90)(91-95)(92-95)(93-94)(93-95)(94-95)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 7 | 0.12 | 10.1039/d4dt01665c | 2024 |
| A549 | 11 | 0.096 | 10.1039/d4dt01665c | 2024 |
| MDA-MB-231 | 12 | 0.1 | 10.1039/d4dt01665c | 2024 |
| HLF | 20 | 0.41 | 10.1039/d4dt01665c | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«When receiving a low-dose one- or two-photon PDT, they become highly potent towards A549 lung cancer cells (with IC50 values ranging from 24.0 nM to 96.0 nM) through the generation of reactive oxygen ...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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