Info
| ID | 6088 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5a |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1cnc2c(c1)c1nc(-c3ccc4c(c3)OCCO4)[nH]c1c1cccnc12 |
TUCAN
C43H30IrN6O2/(1-41)(2-42)(3-43)(4-60)(5-71)(6-37)(7-49)(8-35)(9-36)(10-38)(11-52)(12-71)(13-50)(14-39)(15-40)(16-48)(17-59)(18-45)(19-33)(20-61)(21-34)(22-47)(23-46)(24-70)(25-70)(26-51)(27-53)(28-62)(29-44)(30-75)(31-35)(31-54)(32-53)(32-58)(33-55)(33-72)(34-45)(34-55)(35-41)(36-41)(36-42)(37-43)(37-60)(38-43)(38-65)(39-44)(39-49)(40-47)(40-59)(42-54)(44-53)(45-73)(46-48)(46-61)(47-57)(48-56)(49-58)(50-51)(50-52)(51-68)(52-62)(54-65)(55-69)(56-63)(56-66)(57-64)(57-67)(58-68)(59-78)(60-76)(61-74)(62-79)(63-64)(63-75)(64-77)(65-76)(66-67)(66-74)(67-78)(68-79)(69-75)(69-77)(70-71)(70-80)(71-81)(72-73)(72-80)(73-81)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | — | 8.2 | 10.1039/d4dt01677g | 2024 |
| A549 | — | 0.58 | 10.1039/d4dt01677g | 2024 |
| NIH-3T3 | — | 1.6 | 10.1039/d4dt01677g | 2024 |
🧬 Cell Death Types (3)
Apoptosis
high
«Biological experiments such as migration, cellular localization, mitochondrial membrane potential and permeability, reactive oxygen species (ROS) and calcium ion level detection were performed, and th...»
Ferroptosis
high
«the content of the lipid peroxidation product, malondialdehyde (MDA), increased and the expression of GPX4 decreased. These indicate that the compounds promote cell death by combining ferroptosis and ...»
Pyroptosis
high
«oxidative stress caused by ROS production increases the release of damage-related molecules and the expression of porogen gasdermin D (GSDMD), and the content of LDH released from damaged cell membran...»