Info
| ID | 6088 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 5a |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1cnc2c(c1)c1nc(-c3ccc4c(c3)OCCO4)[nH]c1c1cccnc12 |
TUCAN
C43H30IrN6O2/(1-41)(2-42)(3-43)(4-60)(5-71)(6-37)(7-49)(8-35)(9-36)(10-38)(11-52)(12-71)(13-50)(14-39)(15-40)(16-48)(17-59)(18-45)(19-33)(20-61)(21-34)(22-47)(23-46)(24-70)(25-70)(26-51)(27-53)(28-62)(29-44)(30-75)(31-35)(31-54)(32-53)(32-58)(33-55)(33-72)(34-45)(34-55)(35-41)(36-41)(36-42)(37-43)(37-60)(38-43)(38-65)(39-44)(39-49)(40-47)(40-59)(42-54)(44-53)(45-73)(46-48)(46-61)(47-57)(48-56)(49-58)(50-51)(50-52)(51-68)(52-62)(54-65)(55-69)(56-63)(56-66)(57-64)(57-67)(58-68)(59-78)(60-76)(61-74)(62-79)(63-64)(63-75)(64-77)(65-76)(66-67)(66-74)(67-78)(68-79)(69-75)(69-77)(70-71)(70-80)(71-81)(72-73)(72-80)(73-81)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| BEL-7402 | — | 8.2 | 10.1039/d4dt01677g | 2024 |
| A549 | — | 0.58 | 10.1039/d4dt01677g | 2024 |
| NIH-3T3 | — | 1.6 | 10.1039/d4dt01677g | 2024 |
🧬 Cell Death Types (3)
Apoptosis
high
«Biological experiments such as migration, cellular localization, mitochondrial membrane potential and permeability, reactive oxygen species (ROS) and calcium ion level detection were performed, and th...»
Ferroptosis
high
«the content of the lipid peroxidation product, malondialdehyde (MDA), increased and the expression of GPX4 decreased. These indicate that the compounds promote cell death by combining ferroptosis and ...»
Pyroptosis
high
«oxidative stress caused by ROS production increases the release of damage-related molecules and the expression of porogen gasdermin D (GSDMD), and the content of LDH released from damaged cell membran...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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