Info
| ID | 608 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru8S |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1.Cc1cc2cccnc2c2ncccc12.Cc1cc2cccnc2c2ncccc12 |
TUCAN
C47H36ClF3N8O3Ru/(1-37)(2-43)(3-39)(4-67)(5-40)(6-42)(7-54)(8-37)(9-49)(10-69)(11-66)(12-68)(13-37)(14-65)(15-65)(16-65)(17-53)(18-46)(19-57)(20-50)(21-38)(22-41)(23-70)(24-47)(25-51)(26-48)(27-45)(28-56)(29-38)(30-55)(31-38)(32-44)(33-52)(34-85)(35-86)(36-84)(37-59)(38-64)(39-40)(39-66)(40-58)(41-44)(41-68)(42-54)(42-67)(43-58)(43-59)(44-60)(45-53)(45-76)(46-61)(46-74)(47-48)(47-74)(48-83)(49-55)(49-69)(50-60)(50-64)(51-75)(51-78)(52-70)(52-78)(53-79)(54-62)(55-63)(56-57)(56-76)(57-79)(58-71)(59-62)(60-73)(61-82)(61-83)(62-72)(63-64)(63-77)(65-85)(66-88)(67-87)(68-89)(69-90)(70-91)(71-72)(71-88)(72-87)(73-77)(73-89)(74-84)(75-80)(75-91)(76-86)(77-90)(78-94)(79-94)(80-85)(80-92)(81-84)(81-86)(81-93)(82-95)(82-96)(82-97)(83-98)(87-99)(88-99)(89-99)(90-99)(91-99)(94-99)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HEK293T | 17 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| Caco-2 | 20 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HepG2 | 26 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| MCF-7 | 33 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HT-29 | 34 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| A549 | 92 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the apoptosis results, Ru3S decreased the live cell percentage at all concentrations (p < 0.01) and increased the rate of early apoptotic cells at 3.12 and 12.5 μM concentrations (p < 0.0...»