Info
| ID | 6075 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir-3 |
| SMILES | Fc1c[c-]c(-c2ccccn2)c(F)c1.Fc1c[c-]c(-c2ccccn2)c(F)c1.Oc1cccc2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)nc12 |
TUCAN
C44H25F4IrN7O/(1-41)(2-34)(3-42)(4-46)(5-53)(6-52)(7-32)(8-29)(9-37)(10-38)(11-44)(12-30)(13-55)(14-54)(15-40)(16-36)(17-31)(18-33)(19-43)(20-35)(21-28)(22-45)(23-39)(24-72)(25-77)(26-43)(26-50)(27-45)(27-51)(28-33)(28-35)(29-34)(29-56)(30-34)(30-53)(31-40)(31-48)(32-66)(32-68)(33-65)(35-47)(36-46)(36-54)(37-42)(37-47)(38-41)(38-49)(39-67)(39-69)(40-55)(41-52)(42-59)(43-66)(44-46)(44-63)(45-67)(47-57)(48-60)(48-62)(49-58)(49-61)(50-56)(50-68)(51-63)(51-69)(52-71)(53-74)(54-76)(55-75)(56-74)(57-65)(57-70)(58-60)(58-72)(59-64)(59-70)(60-73)(61-62)(61-71)(62-75)(63-76)(64-72)(64-73)(65-77)(66-79)(67-80)(68-78)(69-81)(73-82)(74-82)(75-82)(76-82)(77-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 8.1 | — | 10.1093/mtomcs/mfac068 | 2022 |
| LO2 | 9.8 | — | 10.1093/mtomcs/mfac068 | 2022 |
| A549 | 10 | — | 10.1093/mtomcs/mfac068 | 2022 |
| HepG2 | 10 | — | 10.1093/mtomcs/mfac068 | 2022 |
| A549cisR | 12 | — | 10.1093/mtomcs/mfac068 | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«Further studies show that Ir-1-3 can specifically accumulate in lysosomes, damage the integrity of lysosomes, and induce apoptosis and autophagy.»
Autophagy
high
«Further studies show that Ir-1-3 can specifically accumulate in lysosomes, damage the integrity of lysosomes, and induce apoptosis and autophagy.»