Info
| ID | 607 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru7S |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1.Clc1cc2cccnc2c2ncccc12.Clc1cc2cccnc2c2ncccc12 |
TUCAN
C45H30Cl3F3N8O3Ru/(1-32)(2-56)(3-39)(4-33)(5-44)(6-58)(7-43)(8-41)(9-34)(10-57)(11-31)(12-35)(13-49)(14-38)(15-46)(16-42)(17-37)(18-48)(19-36)(20-40)(21-55)(22-59)(23-60)(24-55)(25-45)(26-47)(27-55)(28-77)(29-76)(30-78)(31-35)(31-56)(32-33)(32-50)(33-58)(34-37)(34-53)(35-52)(36-45)(36-57)(37-59)(38-39)(38-62)(39-68)(40-42)(40-68)(41-60)(41-69)(42-62)(43-51)(43-61)(44-52)(44-73)(45-54)(46-49)(46-74)(47-67)(47-69)(48-54)(48-75)(49-61)(50-64)(50-73)(51-72)(51-74)(52-63)(53-66)(53-75)(54-65)(55-78)(56-79)(57-82)(58-81)(59-83)(60-80)(61-76)(62-77)(63-64)(63-79)(64-81)(65-66)(65-82)(66-83)(67-70)(67-80)(68-86)(69-86)(70-78)(70-85)(71-76)(71-77)(71-84)(72-87)(72-88)(72-89)(73-90)(74-91)(75-92)(79-93)(80-93)(81-93)(82-93)(83-93)(86-93)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 10 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HT-29 | 15 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| Caco-2 | 17 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HepG2 | 30 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| A549 | 1.7e+02 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HEK293T | 7.6e+02 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the apoptosis results, Ru3S decreased the live cell percentage at all concentrations (p < 0.01) and increased the rate of early apoptotic cells at 3.12 and 12.5 μM concentrations (p < 0.0...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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