Info
| ID | 6056 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/c2nc3c4cccnc4c4ncccc4c3[nH]2)C(C)(C)CCC1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C54H50IrN6/(1-77)(2-60)(3-65)(4-82)(5-82)(6-59)(7-73)(8-83)(9-53)(10-83)(11-63)(12-81)(13-64)(14-94)(15-58)(16-76)(17-62)(18-80)(19-95)(20-97)(21-66)(22-75)(23-52)(24-55)(25-67)(26-55)(27-68)(28-51)(29-71)(30-72)(31-51)(32-51)(33-69)(34-53)(35-53)(36-54)(37-96)(38-84)(39-79)(40-52)(41-55)(42-70)(43-54)(44-54)(45-78)(46-84)(47-61)(48-52)(49-74)(50-106)(51-88)(52-87)(53-93)(54-93)(55-89)(56-58)(56-90)(57-75)(57-92)(58-64)(59-63)(59-64)(60-65)(60-98)(61-79)(61-100)(62-66)(62-80)(63-90)(65-76)(66-75)(67-68)(67-74)(68-88)(69-70)(69-85)(70-95)(71-72)(71-88)(72-86)(73-89)(73-104)(74-89)(76-94)(77-81)(77-97)(78-79)(78-96)(80-92)(81-91)(82-83)(82-87)(83-84)(84-93)(85-102)(85-103)(86-87)(86-93)(90-98)(91-99)(91-101)(92-100)(94-107)(95-105)(96-108)(97-110)(98-107)(99-103)(99-110)(100-108)(101-102)(101-109)(102-106)(103-105)(104-106)(104-109)(107-111)(108-111)(109-111)(110-111)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16 | 0.4 | — | 10.1016/j.ejmech.2022.115046 | 2023 |
| EC109 | 2.5 | — | 10.1016/j.ejmech.2022.115046 | 2023 |
| BEL-7402 | 5.2 | — | 10.1016/j.ejmech.2022.115046 | 2023 |
| LO2 | 7.1 | — | 10.1016/j.ejmech.2022.115046 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The experiments of cellular uptake, mitochondrial localization, and intracellular distribution of the drugs proved that the three iridium(III) complexes can enter the mitochondria, leading to the loss...»