Info
| ID | 6052 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir5 |
| SMILES | NCc1ccccn1.[c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.[c-]1ccccc1-c1nccc2cc3c(cc12)OCO3 |
TUCAN
C38H28IrN4O4/(1-36)(2-42)(3-47)(4-56)(5-44)(6-38)(7-35)(8-34)(9-54)(10-33)(11-65)(12-66)(13-45)(14-66)(15-57)(16-39)(17-40)(18-43)(19-41)(20-65)(21-32)(22-37)(23-31)(24-57)(25-46)(26-55)(27-67)(28-67)(29-35)(29-49)(30-37)(30-51)(31-52)(31-64)(32-53)(32-62)(33-48)(33-63)(34-40)(34-49)(35-47)(36-43)(36-45)(37-45)(38-46)(38-59)(39-46)(39-55)(40-47)(41-48)(41-56)(42-50)(42-61)(43-51)(44-52)(44-54)(48-50)(49-60)(50-60)(51-58)(52-53)(53-58)(54-68)(55-69)(56-70)(57-59)(57-67)(58-68)(59-69)(60-70)(61-63)(61-74)(62-64)(62-73)(63-72)(64-71)(65-72)(65-74)(66-71)(66-73)(68-75)(69-75)(70-75)(74-75)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 3.1 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| NCI-H460 | 5.7 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| A549 | 6.3 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| MGC-803 | 6.4 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
🧬 Cell Death Types (3)
Autophagy
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Ferroptosis
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Immunogenic Cell Death
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»