Info
| ID | 6051 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir4 |
| SMILES | [c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.[c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.c1ccc(-c2ccccn2)nc1 |
TUCAN
C42H28IrN4O4/(1-38)(2-33)(3-32)(4-31)(5-34)(6-57)(7-35)(8-59)(9-36)(10-69)(11-50)(12-69)(13-60)(14-43)(15-37)(16-39)(17-48)(18-58)(19-44)(20-46)(21-49)(22-41)(23-70)(24-42)(25-47)(26-70)(27-45)(28-40)(29-36)(29-52)(30-39)(30-53)(31-36)(31-37)(32-37)(32-52)(33-35)(33-42)(34-54)(34-65)(35-57)(38-51)(38-59)(39-45)(40-45)(40-46)(41-56)(41-60)(42-62)(43-44)(43-58)(44-47)(46-53)(47-63)(48-51)(48-67)(49-56)(49-68)(50-55)(50-66)(51-54)(52-61)(53-64)(54-61)(55-56)(55-64)(57-71)(58-72)(59-73)(60-74)(61-73)(62-63)(62-71)(63-72)(64-74)(65-67)(65-76)(66-68)(66-78)(67-75)(68-77)(69-75)(69-76)(70-77)(70-78)(71-79)(72-79)(73-79)(74-79)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 2.5 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| NCI-H460 | 3.1 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| MGC-803 | 3.9 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| A549 | 4.2 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
🧬 Cell Death Types (3)
Autophagy
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Ferroptosis
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Immunogenic Cell Death
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»