Info
| ID | 6050 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir3 |
| SMILES | [c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.[c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.c1ccc(-c2nc3ccccc3[nH]2)nc1 |
TUCAN
C44H29IrN5O4/(1-41)(2-34)(3-49)(4-37)(5-38)(6-73)(7-59)(8-61)(9-44)(10-72)(11-52)(12-39)(13-40)(14-60)(15-32)(16-33)(17-73)(18-43)(19-42)(20-45)(21-35)(22-51)(23-46)(24-48)(25-50)(26-47)(27-72)(28-36)(29-74)(30-32)(30-53)(31-35)(31-55)(32-37)(33-37)(33-38)(34-40)(34-65)(35-44)(36-44)(36-45)(38-53)(39-57)(39-68)(40-50)(41-54)(41-71)(42-43)(42-48)(43-62)(45-55)(46-56)(46-61)(47-48)(47-64)(49-57)(49-60)(50-59)(51-56)(51-70)(52-58)(52-69)(53-63)(54-57)(54-63)(55-66)(56-58)(58-66)(59-77)(60-75)(61-78)(62-64)(62-74)(63-75)(64-76)(65-67)(65-77)(66-78)(67-74)(67-76)(68-71)(68-80)(69-70)(69-82)(70-79)(71-81)(72-79)(72-82)(73-80)(73-81)(75-83)(76-83)(77-83)(78-83)(82-83)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 7.1 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| NCI-H460 | 7.8 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| A549 | 8.4 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| MGC-803 | 8.6 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
🧬 Cell Death Types (3)
Autophagy
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Ferroptosis
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Immunogenic Cell Death
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»