Info
| ID | 605 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru5S |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1.COc1ccnc(-c2cc(OC)ccn2)c1.COc1ccnc(-c2cc(OC)ccn2)c1 |
TUCAN
C45H40ClF3N8O7Ru/(1-72)(2-73)(3-72)(4-50)(5-46)(6-73)(7-72)(8-73)(9-45)(10-43)(11-60)(12-41)(13-74)(14-57)(15-48)(16-74)(17-55)(18-56)(19-61)(20-74)(21-42)(22-63)(23-49)(24-51)(25-47)(26-59)(27-59)(28-59)(29-75)(30-62)(31-64)(32-52)(33-75)(34-44)(35-53)(36-75)(37-54)(38-86)(39-88)(40-87)(41-60)(41-76)(42-65)(42-77)(43-66)(43-76)(44-70)(44-78)(45-46)(45-85)(46-68)(47-69)(47-81)(48-50)(48-71)(49-67)(49-79)(50-80)(51-61)(51-77)(52-63)(52-78)(53-62)(53-79)(54-64)(54-81)(55-56)(55-80)(56-71)(57-58)(57-68)(58-84)(58-85)(59-87)(60-89)(61-90)(62-92)(63-91)(64-93)(65-70)(65-90)(66-67)(66-89)(67-92)(68-86)(69-82)(69-93)(70-91)(71-88)(72-96)(73-98)(74-97)(75-99)(76-96)(77-98)(78-99)(79-97)(80-100)(81-100)(82-87)(82-94)(83-86)(83-88)(83-95)(84-101)(84-102)(84-103)(85-104)(89-105)(90-105)(91-105)(92-105)(93-105)(98-105)(99-105)(100-105)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 9.5 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| Caco-2 | 11 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HT-29 | 22 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HepG2 | 27 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| A549 | 35 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HEK293T | 87 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the apoptosis results, Ru3S decreased the live cell percentage at all concentrations (p < 0.01) and increased the rate of early apoptotic cells at 3.12 and 12.5 μM concentrations (p < 0.0...»