Info
| ID | 6048 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ir1 |
| SMILES | [c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.[c-]1ccccc1-c1nccc2cc3c(cc12)OCO3.c1ccc(Nc2ccccn2)nc1 |
TUCAN
C42H29IrN5O4/(1-34)(2-47)(3-61)(4-32)(5-33)(6-71)(7-58)(8-59)(9-37)(10-36)(11-70)(12-51)(13-46)(14-42)(15-71)(16-40)(17-39)(18-41)(19-35)(20-48)(21-44)(22-50)(23-38)(24-43)(25-49)(26-70)(27-45)(28-60)(29-72)(30-32)(30-52)(31-36)(31-54)(32-39)(33-39)(33-40)(34-55)(34-69)(35-42)(35-58)(36-44)(37-44)(37-45)(38-57)(38-60)(40-52)(41-53)(41-68)(42-47)(43-48)(43-59)(45-54)(46-55)(46-61)(47-64)(48-49)(49-65)(50-57)(50-67)(51-56)(51-66)(52-62)(53-55)(53-62)(54-63)(56-57)(56-63)(58-74)(59-75)(60-76)(61-73)(62-73)(63-76)(64-72)(64-74)(65-72)(65-75)(66-67)(66-80)(67-78)(68-69)(68-79)(69-77)(70-78)(70-80)(71-77)(71-79)(73-81)(74-81)(75-81)(76-81)(80-81)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 1.8 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| NCI-H460 | 2 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| A549 | 2.4 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
| MGC-803 | 2.6 | — | 10.1016/j.apsb.2024.06.017 | 2025 |
🧬 Cell Death Types (3)
Autophagy
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Ferroptosis
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»
Immunogenic Cell Death
high
«Ir-1 could trigger autophagy-dependent ferroptosis and a subsequent ferroptosis-dependent ICD response as well as indoleamine 2,3-dioxygenase (IDO) inhibition via reactive oxygen species (ROS)-mediate...»