Info
| ID | 6045 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ir1 |
| SMILES | [c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12.c1cnc2c(c1)c1nc(-c3ccc4nccnc4c3)[nH]c1c1cccnc12 |
TUCAN
C51H32IrN8/(1-35)(2-53)(3-55)(4-42)(5-48)(6-46)(7-36)(8-69)(9-40)(10-39)(11-43)(12-44)(13-57)(14-73)(15-45)(16-54)(17-74)(18-37)(19-47)(20-71)(21-56)(22-38)(23-72)(24-70)(25-58)(26-50)(27-49)(28-41)(29-59)(30-51)(31-52)(32-87)(33-39)(33-63)(34-59)(34-68)(35-65)(35-69)(36-46)(36-65)(37-47)(37-66)(38-45)(38-46)(39-48)(40-42)(40-48)(41-49)(41-52)(42-63)(43-49)(43-67)(44-67)(44-70)(45-60)(47-75)(50-51)(50-58)(51-68)(52-64)(53-54)(53-73)(54-62)(55-57)(55-61)(56-66)(56-81)(57-74)(58-59)(60-65)(60-76)(61-77)(61-78)(62-79)(62-82)(63-76)(64-67)(64-80)(66-83)(68-80)(69-88)(70-89)(71-72)(71-85)(72-86)(73-91)(74-84)(75-81)(75-85)(76-88)(77-79)(77-84)(78-82)(78-87)(79-91)(80-89)(81-86)(82-90)(83-87)(83-90)(88-92)(89-92)(90-92)(91-92)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 4.2 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| A549 | 8.1 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| Hepa1-6 | 10 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| A549cisR | 12 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| MB49 | 14 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| LLC | 14 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| MCF-7 | 18 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| K7M2-wt | 20 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| LO2 | 24 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| 4T1 | 26 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
| HeLa | 37 | — | 10.1016/j.bioorg.2023.106837 | 2023 |
🧬 Cell Death Types (2)
Immunogenic Cell Death
high
«Notably, Ir1 also induced immunogenic cell death (ICD), promoted dendritic cell maturation...»
Paraptosis
high
«Ir1 localized in the lysosome, where it induced paraptosis and endoplasmic reticulum stress (ER stress).»