Info
| ID | 6043 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | IrL8 |
| SMILES | COC(=O)c1ccnc(-c2[c-]cc(OC)c(OC)c2)c1.COC(=O)c1ccnc(-c2[c-]cc(OC)c(OC)c2)c1.Nc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C48H39IrN7O8/(1-50)(2-54)(3-79)(4-80)(5-52)(6-44)(7-48)(8-76)(9-78)(10-78)(11-77)(12-56)(13-46)(14-78)(15-64)(16-42)(17-79)(18-80)(19-76)(20-47)(21-65)(22-76)(23-77)(24-77)(25-55)(26-81)(27-81)(28-66)(29-45)(30-81)(31-53)(32-51)(33-49)(34-80)(35-79)(36-63)(37-43)(38-88)(39-88)(40-49)(40-61)(41-55)(41-58)(42-51)(42-71)(43-62)(43-73)(44-48)(44-64)(45-60)(45-66)(46-58)(46-85)(47-54)(47-65)(48-57)(49-82)(50-74)(50-75)(51-74)(52-62)(52-63)(53-61)(53-84)(54-59)(55-83)(56-60)(56-69)(57-68)(57-70)(58-69)(59-67)(59-72)(60-87)(61-73)(62-86)(63-93)(64-89)(65-91)(66-94)(67-68)(67-91)(68-89)(69-94)(70-72)(70-90)(71-75)(71-92)(72-92)(73-93)(74-88)(75-90)(76-98)(77-100)(78-102)(79-99)(80-97)(81-101)(82-84)(82-99)(83-85)(83-100)(84-97)(85-102)(86-95)(86-98)(87-96)(87-101)(91-103)(92-103)(93-103)(94-103)(100-103)(101-103)(102-103)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | — | — | 10.1002/smll.202406809 | 2025 |
| MCF-7 | — | — | 10.1002/smll.202406809 | 2025 |
| A549 | — | — | 10.1002/smll.202406809 | 2025 |
| PC-3 | — | — | 10.1002/smll.202406809 | 2025 |
| HCT-116 | — | — | 10.1002/smll.202406809 | 2025 |
| HEK293 | — | — | 10.1002/smll.202406809 | 2025 |
🧬 Cell Death Types (1)
Ferroptosis
high
«In cell, investigation confirms that IrL1 nanoaggregates internalization via energy-dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA-MB-231 cells.»