Info
| ID | 6042 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | IrL7 |
| SMILES | COC(=O)c1ccnc(-c2[c-]cc(O)cc2)c1.COC(=O)c1ccnc(-c2[c-]cc(O)cc2)c1.Nc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C44H31IrN7O6/(1-47)(2-58)(3-48)(4-42)(5-35)(6-34)(7-44)(8-71)(9-37)(10-41)(11-36)(12-50)(13-39)(14-49)(15-71)(16-57)(17-59)(18-38)(19-60)(20-70)(21-46)(22-40)(23-45)(24-43)(25-71)(26-70)(27-70)(28-76)(29-76)(30-85)(31-86)(32-38)(32-55)(33-44)(33-53)(34-39)(34-57)(35-52)(35-59)(36-41)(36-73)(37-56)(37-69)(38-73)(39-51)(40-52)(40-68)(41-55)(42-43)(42-72)(43-53)(44-72)(45-48)(45-63)(46-49)(46-54)(47-61)(47-64)(48-61)(49-58)(50-56)(50-60)(51-62)(51-67)(52-74)(53-68)(54-65)(54-66)(55-69)(56-75)(57-78)(58-80)(59-81)(60-82)(61-76)(62-65)(62-77)(63-64)(63-79)(64-77)(65-79)(66-67)(66-80)(67-78)(68-81)(69-82)(70-87)(71-88)(72-85)(73-86)(74-83)(74-88)(75-84)(75-87)(79-89)(80-89)(81-89)(82-89)(86-89)(87-89)(88-89)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 4.1 | — | 10.1002/smll.202406809 | 2025 |
| MDA-MB-231 | — | — | 10.1002/smll.202406809 | 2025 |
| MCF-7 | — | — | 10.1002/smll.202406809 | 2025 |
| A549 | — | — | 10.1002/smll.202406809 | 2025 |
| PC-3 | — | — | 10.1002/smll.202406809 | 2025 |
| HEK293 | — | — | 10.1002/smll.202406809 | 2025 |
🧬 Cell Death Types (1)
Ferroptosis
high
«In cell, investigation confirms that IrL1 nanoaggregates internalization via energy-dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA-MB-231 cells.»