Info
| ID | 6041 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | IrL6 |
| SMILES | CCOc1c[c-]c(-c2cc(C(=O)OC)ccn2)cc1.CCOc1c[c-]c(-c2cc(C(=O)OC)ccn2)cc1.Nc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C48H39IrN7O6/(1-50)(2-57)(3-81)(4-41)(5-54)(6-68)(7-55)(8-53)(9-81)(10-40)(11-60)(12-49)(13-70)(14-80)(15-82)(16-44)(17-83)(18-81)(19-41)(20-46)(21-45)(22-67)(23-51)(24-40)(25-58)(26-80)(27-80)(28-59)(29-40)(30-41)(31-52)(32-69)(33-47)(34-56)(35-83)(36-48)(37-82)(38-88)(39-88)(40-82)(41-83)(42-48)(42-64)(43-57)(43-63)(44-50)(44-67)(45-52)(45-68)(46-54)(46-63)(47-53)(47-76)(48-84)(49-60)(49-64)(50-61)(51-62)(51-71)(52-65)(53-78)(54-85)(55-75)(55-78)(56-62)(56-69)(57-85)(58-66)(58-70)(59-66)(59-72)(60-84)(61-73)(61-74)(62-86)(63-71)(64-72)(65-77)(65-79)(66-87)(67-90)(68-93)(69-91)(70-92)(71-91)(72-92)(73-79)(73-89)(74-77)(74-90)(75-76)(75-89)(76-94)(77-93)(78-88)(79-94)(80-100)(81-97)(82-99)(83-98)(84-99)(85-98)(86-95)(86-97)(87-96)(87-100)(91-101)(92-101)(93-101)(94-101)(98-101)(99-101)(100-101)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.47 | — | 10.1002/smll.202406809 | 2025 |
| PC-3 | 0.97 | — | 10.1002/smll.202406809 | 2025 |
| MDA-MB-231 | 1 | — | 10.1002/smll.202406809 | 2025 |
| A549 | 1.7 | — | 10.1002/smll.202406809 | 2025 |
| HCT-116 | 2 | — | 10.1002/smll.202406809 | 2025 |
| HEK293 | 2.1 | — | 10.1002/smll.202406809 | 2025 |
🧬 Cell Death Types (1)
Ferroptosis
high
«In cell, investigation confirms that IrL1 nanoaggregates internalization via energy-dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA-MB-231 cells.»