Info
| ID | 6040 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | IrL5 |
| SMILES | COC(=O)c1ccnc(-c2[c-]cc(C=O)cc2)c1.COC(=O)c1ccnc(-c2[c-]cc(C=O)cc2)c1.Nc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C46H31IrN7O6/(1-45)(2-34)(3-46)(4-36)(5-42)(6-61)(7-72)(8-35)(9-37)(10-74)(11-72)(12-40)(13-60)(14-59)(15-50)(16-47)(17-72)(18-41)(19-62)(20-39)(21-73)(22-49)(23-73)(24-44)(25-38)(26-43)(27-75)(28-48)(29-73)(30-78)(31-78)(32-36)(32-54)(33-41)(33-57)(34-40)(34-60)(35-37)(35-54)(36-53)(37-53)(38-50)(38-56)(39-51)(39-59)(40-52)(41-56)(42-51)(42-64)(43-46)(43-66)(44-47)(44-55)(45-63)(45-67)(46-63)(47-61)(48-58)(48-62)(49-58)(49-71)(50-57)(51-76)(52-65)(52-70)(53-74)(54-64)(55-68)(55-69)(56-75)(57-71)(58-77)(59-83)(60-80)(61-82)(62-84)(63-78)(64-83)(65-68)(65-79)(66-67)(66-81)(67-79)(68-81)(69-70)(69-82)(70-80)(71-84)(72-89)(73-90)(74-87)(75-88)(76-85)(76-89)(77-86)(77-90)(81-91)(82-91)(83-91)(84-91)(89-91)(90-91)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | — | — | 10.1002/smll.202406809 | 2025 |
| MCF-7 | — | — | 10.1002/smll.202406809 | 2025 |
| A549 | — | — | 10.1002/smll.202406809 | 2025 |
| PC-3 | — | — | 10.1002/smll.202406809 | 2025 |
| HCT-116 | — | — | 10.1002/smll.202406809 | 2025 |
| HEK293 | — | — | 10.1002/smll.202406809 | 2025 |
🧬 Cell Death Types (1)
Ferroptosis
high
«In cell, investigation confirms that IrL1 nanoaggregates internalization via energy-dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA-MB-231 cells.»