Info
| ID | 6036 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | IrL1 |
| SMILES | COC(=O)c1ccnc(-c2[c-]cccc2)c1.COC(=O)c1ccnc(-c2[c-]cccc2)c1.Nc1ccc2nc3c4cccnc4c4ncccc4c3nc2c1 |
TUCAN
C44H31IrN7O4/(1-34)(2-45)(3-60)(4-40)(5-37)(6-36)(7-72)(8-47)(9-59)(10-39)(11-46)(12-38)(13-48)(14-50)(15-43)(16-42)(17-72)(18-52)(19-44)(20-62)(21-72)(22-73)(23-35)(24-73)(25-49)(26-51)(27-61)(28-41)(29-73)(30-76)(31-76)(32-42)(32-53)(33-52)(33-58)(34-63)(34-66)(35-40)(35-62)(36-38)(36-42)(37-38)(37-53)(39-57)(39-60)(40-56)(41-54)(41-61)(43-44)(43-50)(44-52)(45-47)(45-59)(46-49)(46-67)(47-55)(48-57)(48-64)(49-63)(50-58)(51-54)(51-71)(53-64)(54-74)(55-65)(55-70)(56-68)(56-69)(57-75)(58-71)(59-78)(60-80)(61-81)(62-82)(63-76)(64-80)(65-69)(65-77)(66-67)(66-77)(67-79)(68-70)(68-82)(69-79)(70-78)(71-81)(72-85)(73-86)(74-83)(74-85)(75-84)(75-86)(79-87)(80-87)(81-87)(82-87)(85-87)(86-87)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.33 | — | 10.1002/smll.202406809 | 2025 |
| PC-3 | 0.51 | — | 10.1002/smll.202406809 | 2025 |
| MCF-7 | 0.64 | — | 10.1002/smll.202406809 | 2025 |
| A549 | 0.82 | — | 10.1002/smll.202406809 | 2025 |
| HCT-116 | 1.3 | — | 10.1002/smll.202406809 | 2025 |
| HEK293 | 2.5 | — | 10.1002/smll.202406809 | 2025 |
🧬 Cell Death Types (1)
Ferroptosis
high
«In cell, investigation confirms that IrL1 nanoaggregates internalization via energy-dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA-MB-231 cells.»