Info
| ID | 6034 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | Ir4 |
| SMILES | Cc1cc(-c2nc3ccccc3s2)[c-]c(-c2nc3ccccc3s2)c1.[Cl-].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C33H21IrN4S2/(1-24)(2-45)(3-25)(4-35)(5-22)(6-46)(7-27)(8-31)(9-34)(10-22)(11-26)(12-28)(13-38)(14-36)(15-33)(16-39)(17-29)(18-22)(19-30)(20-37)(21-32)(22-41)(23-42)(23-44)(24-34)(24-51)(25-27)(25-40)(26-41)(26-42)(27-45)(28-32)(28-46)(29-41)(29-44)(30-36)(30-48)(31-33)(31-40)(32-43)(33-43)(34-36)(35-38)(35-52)(37-39)(37-49)(38-39)(40-47)(42-53)(43-50)(44-54)(45-55)(46-58)(47-50)(47-55)(48-51)(48-56)(49-52)(49-57)(50-58)(51-59)(52-60)(53-56)(53-59)(54-57)(54-60)(55-61)(56-61)(57-61)(58-61)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.1 | — | 10.1016/j.bioorg.2025.108507 | 2025 |
| MGC-803 | 1.7 | — | 10.1016/j.bioorg.2025.108507 | 2025 |
| A549 | 3.9 | — | 10.1016/j.bioorg.2025.108507 | 2025 |
| RKO | 5.1 | — | 10.1016/j.bioorg.2025.108507 | 2025 |
| BEAS-2B | 40 | — | 10.1016/j.bioorg.2025.108507 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«The anticancer mechanism has been explored through apoptosis, cell cycle arrest, western blotting (WB), reactive oxygen species (ROS) levels and mitochondrial membrane potential (MMP) changes.»