Info
| ID | 6030 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir-ART |
| SMILES | CC1CCC2C(C)C(OC(=O)CCC(=O)OCc3ccncc3)OC3CC4CCC1C32OO4.Cc1c(C)c(C)[c-](C)c1C.[c-]1ccccc1-c1ccccn1 |
TUCAN
C46H56IrN2O7/(1-75)(2-57)(3-57)(4-57)(5-75)(6-66)(7-71)(8-58)(9-58)(10-72)(11-67)(12-58)(13-69)(14-59)(15-59)(16-59)(17-92)(18-65)(19-61)(20-60)(21-102)(22-77)(23-93)(24-61)(25-88)(26-89)(27-78)(28-96)(29-96)(30-76)(31-77)(32-70)(33-78)(34-79)(35-94)(36-79)(37-90)(38-60)(39-60)(40-61)(41-98)(42-62)(43-62)(44-97)(45-62)(46-80)(47-63)(48-80)(49-63)(50-73)(51-74)(52-74)(53-91)(54-63)(55-68)(56-76)(57-81)(58-82)(59-85)(60-90)(61-88)(62-86)(63-87)(64-68)(64-83)(65-66)(65-92)(66-69)(67-71)(67-83)(68-72)(69-95)(70-84)(70-93)(71-72)(73-84)(73-94)(74-75)(74-91)(75-98)(76-77)(76-100)(77-101)(78-79)(78-89)(79-90)(80-97)(80-98)(81-82)(81-85)(82-86)(83-95)(84-96)(85-87)(86-87)(88-89)(88-102)(89-99)(90-91)(91-99)(92-103)(93-104)(94-104)(95-103)(96-107)(97-99)(97-109)(98-111)(99-110)(100-105)(100-107)(101-106)(101-108)(102-108)(102-109)(103-112)(104-112)(110-111)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 6.4 | — | 10.1039/d4cb00114a | 2025 |
| MCF-7 | 17 | — | 10.1039/d4cb00114a | 2025 |
| A549 | 21 | — | 10.1039/d4cb00114a | 2025 |
| HeLa | 25 | — | 10.1039/d4cb00114a | 2025 |
🧬 Cell Death Types (2)
Autophagy
high
«Taken together, Ir-ART mediated autophagic cell death in HCT-116 colon cancer cells.»
Immunogenic Cell Death
high
«These results suggested that Ir-ART can be expected to initiate antitumor immune responses by eliciting ICD.»