Info
| ID | 603 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru3S |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1.Cc1cccc(-c2cccc(C)n2)n1.Cc1cccc(-c2cccc(C)n2)n1 |
TUCAN
C45H40ClF3N8O3Ru/(1-47)(2-45)(3-41)(4-55)(5-46)(6-61)(7-62)(8-41)(9-41)(10-48)(11-42)(12-42)(13-49)(14-42)(15-63)(16-43)(17-67)(18-67)(19-54)(20-53)(21-67)(22-65)(23-60)(24-43)(25-50)(26-68)(27-43)(28-52)(29-56)(30-64)(31-51)(32-44)(33-59)(34-58)(35-57)(36-44)(37-44)(38-88)(39-87)(40-86)(41-71)(42-72)(43-75)(44-78)(45-47)(45-69)(46-55)(46-70)(47-48)(48-71)(49-55)(49-72)(50-68)(50-81)(51-52)(51-73)(52-85)(53-54)(53-77)(54-80)(56-62)(56-75)(57-64)(57-78)(58-59)(58-77)(59-80)(60-66)(60-73)(61-62)(61-74)(63-64)(63-76)(65-79)(65-81)(66-84)(66-85)(67-88)(68-93)(69-70)(69-89)(70-90)(71-89)(72-90)(73-86)(74-76)(74-91)(75-91)(76-92)(77-87)(78-92)(79-82)(79-93)(80-96)(81-96)(82-88)(82-95)(83-86)(83-87)(83-94)(84-97)(84-98)(84-99)(85-100)(89-101)(90-101)(91-101)(92-101)(93-101)(96-101)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HT-29 | 6.9 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HepG2 | 7.1 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| Caco-2 | 9.6 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| MCF-7 | 12 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| A549 | 25 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HEK293T | 84 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the apoptosis results, Ru3S decreased the live cell percentage at all concentrations (p < 0.01) and increased the rate of early apoptotic cells at 3.12 and 12.5 μM concentrations (p < 0.0...»
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