Info
| ID | 6029 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ir-OH |
| SMILES | Cc1c(C)c(C)[c-](C)c1C.OCc1ccncc1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C27H30IrN2O/(1-57)(2-31)(3-31)(4-31)(5-32)(6-32)(7-55)(8-40)(9-42)(10-38)(11-45)(12-32)(13-33)(14-33)(15-57)(16-39)(17-53)(18-54)(19-44)(20-43)(21-41)(22-37)(23-33)(24-34)(25-34)(26-34)(27-35)(28-35)(29-35)(30-60)(31-47)(32-48)(33-49)(34-50)(35-51)(36-45)(36-46)(37-38)(37-55)(38-40)(39-52)(39-53)(40-56)(41-42)(41-44)(42-45)(43-52)(43-54)(44-46)(46-56)(47-48)(47-49)(48-50)(49-51)(50-51)(52-57)(53-58)(54-58)(55-59)(56-59)(57-60)(58-61)(59-61)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 23 | — | 10.1039/d4cb00114a | 2025 |
| MCF-7 | 26 | — | 10.1039/d4cb00114a | 2025 |
| HeLa | 39 | — | 10.1039/d4cb00114a | 2025 |
| A549 | 48 | — | 10.1039/d4cb00114a | 2025 |
🧬 Cell Death Types (2)
Autophagy
high
«Taken together, Ir-ART mediated autophagic cell death in HCT-116 colon cancer cells.»
Immunogenic Cell Death
high
«These results suggested that Ir-ART can be expected to initiate antitumor immune responses by eliciting ICD.»