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Complex #6025 — Ir(3) [Ir3]

2D Structure

Structure
⬇ MOL V3000

Info

ID6025
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 7}
AbbreviationIr3
SMILESO=c1[nH]c(=O)n(CCCCNc2cc3cccnc3c3ncccc23)cc1F.[c-]1ccsc1-c1ccccn1.[c-]1ccsc1-c1ccccn1

TUCAN

C38H30FIrN7O2S2/(1-65)(2-35)(3-50)(4-33)(5-52)(6-54)(7-47)(8-43)(9-36)(10-66)(11-39)(12-56)(13-34)(14-55)(15-46)(16-40)(17-51)(18-42)(19-53)(20-47)(21-44)(22-55)(23-41)(24-37)(25-45)(26-38)(27-46)(28-56)(29-70)(30-69)(31-36)(31-67)(32-44)(32-68)(33-34)(33-57)(34-37)(35-42)(35-50)(36-65)(37-51)(38-39)(38-53)(39-49)(40-41)(40-48)(41-54)(42-45)(43-49)(43-61)(44-66)(45-58)(46-47)(46-55)(47-56)(48-60)(48-61)(49-59)(50-72)(51-74)(52-64)(52-71)(53-73)(54-75)(55-71)(56-69)(57-67)(57-74)(58-68)(58-72)(59-60)(59-73)(60-75)(61-69)(62-64)(62-70)(62-76)(63-70)(63-71)(63-77)(64-78)(65-79)(66-80)(67-79)(68-80)(72-81)(73-81)(74-81)(75-81)(79-81)(80-81)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HeLa6.4 10.1002/cbic.202400756 2025
KYSE-14019 10.1002/cbic.202400756 2025
Caco-220 10.1002/cbic.202400756 2025
MCF-754 10.1002/cbic.202400756 2025
HepG277 10.1002/cbic.202400756 2025

🧬 Cell Death Types (1)

Apoptosis high
«Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction.»