Info
| ID | 6024 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ir2 |
| SMILES | O=c1[nH]c(=O)n(CCCCNc2cc3cccnc3c3ncccc23)cc1F.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C46H34FIrN7O2/(1-41)(2-37)(3-45)(4-40)(5-51)(6-43)(7-52)(8-44)(9-66)(10-57)(11-56)(12-72)(13-72)(14-56)(15-71)(16-55)(17-69)(18-47)(19-70)(20-50)(21-67)(22-38)(23-54)(24-57)(25-71)(26-48)(27-53)(28-68)(29-49)(30-39)(31-42)(32-46)(33-81)(34-82)(35-45)(35-58)(36-50)(36-63)(37-41)(37-66)(38-40)(38-59)(39-44)(39-67)(40-45)(41-60)(42-46)(42-50)(43-51)(43-60)(44-61)(46-64)(47-49)(47-68)(48-62)(48-77)(49-65)(51-59)(52-54)(52-61)(53-55)(53-69)(54-64)(55-62)(56-57)(56-72)(57-71)(58-59)(58-73)(60-73)(61-76)(62-75)(63-64)(63-76)(65-74)(65-77)(66-84)(67-87)(68-85)(69-86)(70-80)(70-83)(71-82)(72-83)(73-84)(74-75)(74-85)(75-86)(76-87)(77-82)(78-80)(78-81)(78-88)(79-81)(79-83)(79-89)(80-90)(84-91)(85-91)(86-91)(87-91)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5.4 | — | 10.1002/cbic.202400756 | 2025 |
| KYSE-140 | 15 | — | 10.1002/cbic.202400756 | 2025 |
| Caco-2 | 22 | — | 10.1002/cbic.202400756 | 2025 |
| MCF-7 | 34 | — | 10.1002/cbic.202400756 | 2025 |
| HepG2 | 1.3e+02 | — | 10.1002/cbic.202400756 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction.»