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Complex #6023 — Ir(3) [Ir1]

2D Structure

Structure
⬇ MOL V3000

Info

ID6023
MetalIr
Oxidation state3
Charge1
Donor atoms{"N": 7}
AbbreviationIr1
SMILESO=c1[nH]c(=O)n(CCCCNc2cc3cccnc3c3ncccc23)cc1F.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12

TUCAN

C50H38FIrN7O2/(1-43)(2-44)(3-41)(4-47)(5-55)(6-60)(7-50)(8-54)(9-46)(10-56)(11-45)(12-42)(13-79)(14-65)(15-65)(16-64)(17-79)(18-80)(19-53)(20-78)(21-52)(22-49)(23-74)(24-75)(25-76)(26-58)(27-64)(28-62)(29-63)(30-77)(31-61)(32-57)(33-59)(34-51)(35-48)(36-80)(37-90)(38-89)(39-50)(39-69)(40-54)(40-71)(41-42)(41-43)(42-66)(43-45)(44-47)(44-50)(45-68)(46-48)(46-49)(47-57)(48-58)(49-72)(51-52)(51-67)(52-77)(53-63)(53-73)(54-60)(55-59)(55-60)(56-68)(56-74)(57-69)(58-70)(59-71)(61-72)(61-75)(62-73)(62-84)(63-78)(64-65)(64-80)(65-79)(66-68)(66-81)(67-83)(67-84)(69-81)(70-72)(70-85)(71-85)(73-82)(74-92)(75-94)(76-88)(76-91)(77-95)(78-93)(79-90)(80-91)(81-92)(82-83)(82-93)(83-95)(84-90)(85-94)(86-88)(86-89)(86-96)(87-89)(87-91)(87-97)(88-98)(92-99)(93-99)(94-99)(95-99)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HeLa3 10.1002/cbic.202400756 2025
KYSE-1406.1 10.1002/cbic.202400756 2025
MCF-79.3 10.1002/cbic.202400756 2025
Caco-215 10.1002/cbic.202400756 2025
HepG21.1e+02 10.1002/cbic.202400756 2025

🧬 Cell Death Types (1)

Apoptosis high
«Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction.»