Info
| ID | 602 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru2S |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1.Cc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1 |
TUCAN
C45H40ClF3N8O3Ru/(1-68)(2-45)(3-41)(4-69)(5-41)(6-46)(7-57)(8-47)(9-70)(10-48)(11-41)(12-49)(13-72)(14-54)(15-51)(16-61)(17-55)(18-42)(19-71)(20-42)(21-56)(22-42)(23-53)(24-50)(25-43)(26-43)(27-67)(28-52)(29-43)(30-59)(31-44)(32-44)(33-58)(34-60)(35-44)(36-67)(37-67)(38-88)(39-87)(40-86)(41-62)(42-63)(43-64)(44-65)(45-62)(45-73)(46-63)(46-74)(47-62)(47-68)(48-64)(48-69)(49-65)(49-70)(50-71)(50-81)(51-54)(51-77)(52-53)(52-75)(53-85)(54-80)(55-66)(55-75)(56-63)(56-72)(57-64)(57-76)(58-59)(58-77)(59-80)(60-65)(60-78)(61-79)(61-81)(66-84)(66-85)(67-87)(68-89)(69-90)(70-91)(71-92)(72-93)(73-74)(73-89)(74-93)(75-86)(76-78)(76-90)(77-88)(78-91)(79-82)(79-92)(80-96)(81-96)(82-87)(82-95)(83-86)(83-88)(83-94)(84-97)(84-98)(84-99)(85-100)(89-101)(90-101)(91-101)(92-101)(93-101)(96-101)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| Caco-2 | 11 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| MCF-7 | 18 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HT-29 | 19 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HepG2 | 79 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| A549 | 94 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
| HEK293T | 1.4e+02 | — | 10.1021/acs.jmedchem.3c01115 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«According to the apoptosis results, Ru3S decreased the live cell percentage at all concentrations (p < 0.01) and increased the rate of early apoptotic cells at 3.12 and 12.5 μM concentrations (p < 0.0...»