Info
| ID | 6017 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | 7b |
| SMILES | Cc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c(O)c1.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C46H30IrN6O/(1-48)(2-35)(3-34)(4-37)(5-45)(6-39)(7-36)(8-65)(9-49)(10-31)(11-41)(12-53)(13-68)(14-43)(15-47)(16-40)(17-38)(18-67)(19-31)(20-54)(21-66)(22-42)(23-44)(24-50)(25-46)(26-51)(27-52)(28-31)(29-78)(30-83)(31-59)(32-36)(32-55)(33-49)(33-56)(34-37)(34-65)(35-36)(35-39)(37-57)(38-47)(38-57)(39-61)(40-52)(40-58)(41-53)(41-59)(42-43)(42-60)(43-66)(44-59)(44-76)(45-49)(45-50)(46-51)(46-58)(47-61)(48-54)(48-64)(50-63)(51-63)(52-67)(53-62)(54-68)(55-61)(55-69)(56-63)(56-71)(57-69)(58-71)(60-73)(60-74)(62-75)(62-76)(64-70)(64-72)(65-79)(66-77)(67-81)(68-82)(69-79)(70-74)(70-80)(71-81)(72-73)(72-82)(73-77)(74-78)(75-78)(75-80)(76-83)(79-84)(80-84)(81-84)(82-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 4.5 | — | 10.1016/j.ejmech.2025.117926 | 2025 |
| LA795 | 8.3 | — | 10.1016/j.ejmech.2025.117926 | 2025 |
| NIH-3T3 | 12 | — | 10.1016/j.ejmech.2025.117926 | 2025 |
🧬 Cell Death Types (5)
Apoptosis
high
«release of cytochrome c, collectively leading to apoptosis»
Autophagy
high
«upregulation of Beclin-1 ... resulted in the activation of autophagy»
Ferroptosis
high
«downregulation of GPX4 protein ... resulted in the activation of ... ferroptosis»
Immunogenic Cell Death
high
«the complexes induce an immunogenic cell death to activate immune response, further enhance CD8+ T cells»
Pyroptosis
high
«overexpression of NF-κB ... resulted in the activation of ... pyroptosis»