Info
| ID | 6001 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir3ʹ |
| SMILES | CCCCOc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.COc1c[c-]c(-c2ccccn2)cc1.COc1c[c-]c(-c2ccccn2)cc1 |
TUCAN
C47H40IrN6O3/(1-51)(2-82)(3-82)(4-55)(5-83)(6-82)(7-72)(8-60)(9-62)(10-44)(11-83)(12-57)(13-52)(14-56)(15-83)(16-49)(17-59)(18-41)(19-58)(20-61)(21-73)(22-63)(23-50)(24-45)(25-53)(26-84)(27-84)(28-64)(29-41)(30-71)(31-74)(32-46)(33-54)(34-48)(35-47)(36-64)(37-65)(38-65)(39-41)(40-89)(41-65)(42-47)(42-68)(43-46)(43-69)(44-45)(44-60)(45-76)(46-85)(47-86)(48-57)(48-85)(49-52)(49-67)(50-54)(50-66)(51-58)(51-74)(52-87)(53-59)(53-67)(54-73)(55-61)(55-86)(56-62)(56-63)(57-69)(58-70)(59-87)(60-71)(61-68)(62-72)(63-75)(64-65)(64-84)(66-77)(66-79)(67-81)(68-76)(69-75)(70-78)(70-80)(71-90)(72-93)(73-88)(74-92)(75-93)(76-90)(77-78)(77-89)(78-91)(79-80)(79-88)(80-92)(81-89)(81-91)(82-95)(83-94)(84-96)(85-95)(86-94)(87-96)(90-97)(91-97)(92-97)(93-97)(95-97)(96-97)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 36 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| BEAS-2B | 57 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| HeLa | 82 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies confirmed that these complexes selectively target mitochondria ... leading to ... activation of intrinsic apoptosis pathways.»