Info
| ID | 60 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru1 |
| SMILES | CC#N.CC#N.CC#N.CC#N.[c-]1n(-c2ccccn2)cc[n+]1Cc1ccccc1 |
TUCAN
C23N7Ru/(1-14)(2-18)(3-20)(4-21)(5-8)(5-13)(6-9)(6-23)(7-10)(7-13)(8-11)(9-12)(10-11)(12-19)(13-15)(14-24)(15-30)(16-17)(16-29)(17-30)(18-25)(19-28)(20-26)(21-27)(22-29)(22-30)(23-28)(23-29)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | — | — | 10.1002/chem.202002970 | 2020 |
| A2780 | — | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | — | — | 10.1002/chem.202002970 | 2020 |
| B16-F10 | — | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | — | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»