Info
| ID | 5998 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ir5 |
| SMILES | [c-]1ccccc1-n1cccn1.[c-]1ccccc1-n1cccn1.c1ccc([P+](CCCCOc2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C59H48IrN8OP/(1-70)(2-51)(3-85)(4-102)(5-61)(6-73)(7-64)(8-84)(9-102)(10-58)(11-59)(12-63)(13-57)(14-71)(15-52)(16-76)(17-66)(18-104)(19-69)(20-72)(21-91)(22-104)(23-85)(24-74)(25-90)(26-65)(27-77)(28-84)(29-68)(30-67)(31-80)(32-75)(33-82)(34-56)(35-83)(36-93)(37-55)(38-89)(39-78)(40-92)(41-94)(42-60)(43-79)(44-53)(45-81)(46-54)(47-62)(48-109)(49-53)(49-97)(50-81)(50-100)(51-58)(51-105)(52-58)(52-59)(53-60)(54-56)(54-60)(55-89)(55-93)(56-97)(57-65)(57-86)(59-61)(61-105)(62-79)(62-83)(63-64)(63-72)(64-106)(65-103)(66-71)(66-106)(67-82)(67-86)(68-74)(68-107)(69-76)(69-91)(70-73)(70-90)(71-72)(73-87)(74-77)(75-80)(75-107)(76-88)(77-80)(78-92)(78-94)(79-81)(82-103)(83-100)(84-85)(84-104)(85-102)(86-101)(87-95)(87-96)(88-98)(88-99)(89-110)(90-113)(91-108)(92-111)(93-114)(94-115)(95-99)(95-113)(96-98)(96-112)(97-110)(98-109)(99-108)(100-111)(101-109)(101-112)(102-116)(103-116)(104-117)(105-117)(106-117)(107-117)(110-114)(111-115)(112-118)(113-118)(114-118)(115-118)(116-118)(117-118)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 7.2 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| A549 | 9.2 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| BEAS-2B | 50 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies confirmed that these complexes selectively target mitochondria ... leading to ... activation of intrinsic apoptosis pathways.»