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Complex #5998 — Ir(3) [Ir5]

2D Structure

Structure
⬇ MOL V3000

Info

ID5998
MetalIr
Oxidation state3
Charge2
Donor atoms{"N": 8}
AbbreviationIr5
SMILES[c-]1ccccc1-n1cccn1.[c-]1ccccc1-n1cccn1.c1ccc([P+](CCCCOc2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)(c2ccccc2)c2ccccc2)cc1

TUCAN

C59H48IrN8OP/(1-70)(2-51)(3-85)(4-102)(5-61)(6-73)(7-64)(8-84)(9-102)(10-58)(11-59)(12-63)(13-57)(14-71)(15-52)(16-76)(17-66)(18-104)(19-69)(20-72)(21-91)(22-104)(23-85)(24-74)(25-90)(26-65)(27-77)(28-84)(29-68)(30-67)(31-80)(32-75)(33-82)(34-56)(35-83)(36-93)(37-55)(38-89)(39-78)(40-92)(41-94)(42-60)(43-79)(44-53)(45-81)(46-54)(47-62)(48-109)(49-53)(49-97)(50-81)(50-100)(51-58)(51-105)(52-58)(52-59)(53-60)(54-56)(54-60)(55-89)(55-93)(56-97)(57-65)(57-86)(59-61)(61-105)(62-79)(62-83)(63-64)(63-72)(64-106)(65-103)(66-71)(66-106)(67-82)(67-86)(68-74)(68-107)(69-76)(69-91)(70-73)(70-90)(71-72)(73-87)(74-77)(75-80)(75-107)(76-88)(77-80)(78-92)(78-94)(79-81)(82-103)(83-100)(84-85)(84-104)(85-102)(86-101)(87-95)(87-96)(88-98)(88-99)(89-110)(90-113)(91-108)(92-111)(93-114)(94-115)(95-99)(95-113)(96-98)(96-112)(97-110)(98-109)(99-108)(100-111)(101-109)(101-112)(102-116)(103-116)(104-117)(105-117)(106-117)(107-117)(110-114)(111-115)(112-118)(113-118)(114-118)(115-118)(116-118)(117-118)

Measurements (3)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HeLa7.2 10.1016/j.bioorg.2025.108148 2025
A5499.2 10.1016/j.bioorg.2025.108148 2025
BEAS-2B50 10.1016/j.bioorg.2025.108148 2025

🧬 Cell Death Types (1)

Apoptosis high
«Mechanistic studies confirmed that these complexes selectively target mitochondria ... leading to ... activation of intrinsic apoptosis pathways.»