Info
| ID | 5996 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir3 |
| SMILES | COc1c[c-]c(-c2ccccn2)cc1.COc1c[c-]c(-c2ccccn2)cc1.c1ccc([P+](CCCCOc2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C65H54IrN6O3P/(1-99)(2-65)(3-112)(4-93)(5-74)(6-81)(7-63)(8-82)(9-86)(10-70)(11-68)(12-76)(13-60)(14-112)(15-116)(16-77)(17-101)(18-90)(19-87)(20-85)(21-102)(22-88)(23-110)(24-58)(25-69)(26-59)(27-100)(28-75)(29-67)(30-78)(31-72)(32-61)(33-64)(34-79)(35-93)(36-80)(37-57)(38-92)(39-62)(40-116)(41-73)(42-92)(43-84)(44-83)(45-66)(46-110)(47-110)(48-111)(49-91)(50-89)(51-111)(52-71)(53-111)(54-121)(55-71)(55-97)(56-70)(56-98)(57-59)(57-113)(58-61)(58-65)(59-95)(60-67)(60-94)(61-69)(62-75)(62-79)(63-85)(63-97)(64-66)(64-95)(65-117)(66-113)(67-100)(68-72)(68-99)(69-74)(70-114)(71-115)(72-96)(73-80)(73-84)(74-117)(75-76)(76-118)(77-79)(77-118)(78-80)(78-119)(81-82)(81-114)(82-98)(83-84)(83-119)(85-115)(86-88)(86-90)(87-89)(87-91)(88-107)(89-108)(90-101)(91-102)(92-93)(92-112)(93-116)(94-103)(94-105)(95-109)(96-104)(96-106)(97-107)(98-108)(99-123)(100-120)(101-122)(102-125)(103-106)(103-121)(104-105)(104-123)(105-120)(106-124)(107-122)(108-125)(109-121)(109-124)(110-127)(111-128)(112-126)(113-126)(114-127)(115-128)(116-129)(117-129)(118-129)(119-129)(122-130)(123-130)(124-130)(125-130)(127-130)(128-130)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 5.3 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| HeLa | 5.3 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| BEAS-2B | 36 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies confirmed that these complexes selectively target mitochondria ... leading to ... activation of intrinsic apoptosis pathways.»