Info
| ID | 5994 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ir1 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc([P+](CCCCOc2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C63H50IrN6OP/(1-91)(2-99)(3-53)(4-62)(5-66)(6-110)(7-97)(8-108)(9-55)(10-58)(11-74)(12-76)(13-77)(14-54)(15-110)(16-68)(17-60)(18-71)(19-72)(20-90)(21-73)(22-82)(23-90)(24-75)(25-81)(26-78)(27-69)(28-79)(29-108)(30-91)(31-61)(32-80)(33-70)(34-85)(35-83)(36-64)(37-65)(38-98)(39-88)(40-59)(41-100)(42-57)(43-86)(44-63)(45-84)(46-56)(47-87)(48-67)(49-89)(50-115)(51-56)(51-93)(52-87)(52-96)(53-60)(53-109)(54-55)(54-111)(55-62)(56-63)(57-63)(57-67)(58-64)(58-66)(59-65)(59-88)(60-92)(61-69)(61-97)(62-74)(64-105)(65-106)(66-98)(67-93)(68-74)(68-111)(69-95)(70-76)(70-77)(71-76)(71-112)(72-75)(72-109)(73-77)(73-112)(75-92)(78-82)(78-99)(79-81)(79-113)(80-85)(80-113)(81-83)(82-94)(83-85)(84-86)(84-87)(86-89)(88-100)(89-96)(90-91)(90-108)(91-110)(92-107)(93-105)(94-102)(94-104)(95-101)(95-103)(96-106)(97-117)(98-118)(99-114)(100-119)(101-104)(101-117)(102-103)(102-115)(103-116)(104-114)(105-118)(106-119)(107-115)(107-116)(108-120)(109-120)(110-121)(111-121)(112-121)(113-121)(116-122)(117-122)(118-122)(119-122)(120-122)(121-122)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.1 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| HeLa | 4.7 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
| BEAS-2B | 46 | — | 10.1016/j.bioorg.2025.108148 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies confirmed that these complexes selectively target mitochondria ... leading to ... activation of intrinsic apoptosis pathways.»