Info
| ID | 5985 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | OncoIr3 |
| SMILES | CCCCn1c(-c2nc3ccccc3s2)nc2cc(C(=O)OC)ccc21.FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1.FC(F)(F)c1ccc(Cn2c(-c3[c-]cccc3)nc3ccccc32)cc1 |
TUCAN
C62H47F6IrN7O2S/(1-58)(2-55)(3-51)(4-56)(5-54)(6-69)(7-62)(8-91)(9-57)(10-52)(11-53)(12-64)(13-67)(14-92)(15-66)(16-80)(17-68)(18-79)(19-82)(20-92)(21-82)(22-81)(23-48)(24-59)(25-75)(26-63)(27-60)(28-70)(29-74)(30-76)(31-91)(32-72)(33-104)(34-104)(35-83)(36-48)(37-71)(38-77)(39-73)(40-78)(41-93)(42-61)(43-93)(44-65)(45-104)(46-83)(47-48)(48-83)(49-56)(49-86)(50-64)(50-87)(51-59)(51-84)(52-53)(52-56)(53-54)(54-86)(55-58)(55-94)(57-69)(57-95)(58-69)(59-85)(60-62)(60-85)(61-73)(61-76)(62-84)(63-71)(63-75)(64-76)(65-81)(65-88)(66-79)(66-80)(67-80)(67-100)(68-88)(68-99)(70-74)(70-90)(71-77)(72-78)(72-90)(73-87)(74-89)(75-96)(77-97)(78-89)(79-108)(81-98)(82-83)(82-92)(84-106)(85-91)(86-101)(87-103)(88-105)(89-93)(90-107)(91-110)(92-112)(93-111)(94-95)(94-110)(95-113)(96-97)(96-111)(97-114)(98-99)(98-112)(99-116)(100-108)(100-115)(101-110)(101-113)(102-109)(102-112)(102-116)(103-111)(103-114)(104-118)(105-117)(105-118)(106-119)(106-120)(106-121)(107-122)(107-123)(107-124)(108-125)(109-115)(109-125)(113-126)(114-126)(115-126)(116-126)(118-126)(125-126)
Measurements (14)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.19 | — | 10.1007/s00018-022-04526-5 | 2022 |
| A2780cisR | 0.21 | — | 10.1007/s00018-022-04526-5 | 2022 |
| HeLa | 0.4 | — | 10.1007/s00018-022-04526-5 | 2022 |
| MDA-MB-231 | 0.7 | — | 10.1007/s00018-022-04526-5 | 2022 |
| A2780 | 0.91 | — | 10.1007/s00018-022-04526-5 | 2022 |
| A2780cisR | 1 | — | 10.1007/s00018-022-04526-5 | 2022 |
| HeLa | 1.8 | — | 10.1007/s00018-022-04526-5 | 2022 |
| MDA-MB-231 | 2.4 | — | 10.1007/s00018-022-04526-5 | 2022 |
| CHO | 2.6 | — | 10.1007/s00018-022-04526-5 | 2022 |
| A2780 | 5.8 | — | 10.1007/s00018-022-04526-5 | 2022 |
| A2780cisR | 6.5 | — | 10.1007/s00018-022-04526-5 | 2022 |
| HeLa | 8.8 | — | 10.1007/s00018-022-04526-5 | 2022 |
| MDA-MB-231 | 9.6 | — | 10.1007/s00018-022-04526-5 | 2022 |
| BGM | — | — | 10.1007/s00018-022-04526-5 | 2022 |
🧬 Cell Death Types (1)
Oncosis
high
«Flow cytometry and fluorescence-based assays confirmed an apoptosis-independent mechanism involving energy depletion, mitochondrial dysfunction and cellular swelling that matched with the oncotic proc...»