Info
| ID | 5982 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | 8c |
| SMILES | Cn1c(=O)c2nc3c4cccnc4c4ncccc4c3nc2n(C)c1=O.[c-]1ccccc1-c1nccc2ccccc12.[c-]1ccccc1-c1nccc2ccccc12 |
TUCAN
C48H32IrN8O2/(1-54)(2-39)(3-37)(4-36)(5-38)(6-35)(7-44)(8-41)(9-40)(10-42)(11-66)(12-66)(13-56)(14-66)(15-46)(16-65)(17-65)(18-48)(19-49)(20-53)(21-55)(22-43)(23-70)(24-67)(25-45)(26-65)(27-68)(28-69)(29-50)(30-47)(31-51)(32-52)(33-35)(33-61)(34-50)(34-62)(35-41)(36-39)(36-57)(37-38)(37-39)(38-58)(40-41)(40-54)(42-44)(42-59)(43-44)(43-51)(45-46)(45-60)(46-67)(47-53)(47-55)(48-58)(48-68)(49-64)(49-69)(50-53)(51-64)(52-56)(52-70)(54-61)(55-62)(56-63)(57-58)(57-71)(59-64)(59-74)(60-72)(60-73)(61-71)(62-74)(63-75)(63-76)(65-83)(66-84)(67-82)(68-85)(69-86)(70-87)(71-85)(72-75)(72-81)(73-76)(73-82)(74-86)(75-88)(76-87)(77-78)(77-79)(77-88)(78-81)(78-83)(79-84)(79-90)(80-83)(80-84)(80-89)(85-91)(86-91)(87-91)(88-91)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 1.4 | 1 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| B16 | 1.6 | 1.1 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| LO2 | 13 | 5.9 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
🧬 Cell Death Types (4)
Apoptosis
high
«activation of caspase 3 and Bcl-2 family proteins to induce apoptosis»
Autophagy
high
«8a, 8b and 8c induced autophagy by inhibiting the AKT/PI3K/mTOR signaling pathway, downregulating p62 and promoting Beclin-1 expression upon light irradiation»
Ferroptosis
high
«The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess the potential to induce ferroptosis»
Immunogenic Cell Death
medium
«upregulated the expression of the damage-associated molecules, HMGB1, CRT, and HSP70. The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess...»