Info
| ID | 5981 |
| Metal | Ir |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | 8b |
| SMILES | Cn1c(=O)c2nc3c4cccnc4c4ncccc4c3nc2n(C)c1=O.[c-]1cccc2ccc3cccnc3c12.[c-]1cccc2ccc3cccnc3c12 |
TUCAN
C44H28IrN8O2/(1-31)(2-36)(3-33)(4-43)(5-32)(6-35)(7-39)(8-38)(9-34)(10-37)(11-59)(12-58)(13-48)(14-61)(15-46)(16-57)(17-57)(18-44)(19-47)(20-58)(21-58)(22-45)(23-62)(24-40)(25-57)(26-60)(27-42)(28-41)(29-34)(29-51)(30-41)(30-53)(31-33)(31-49)(32-35)(32-50)(33-59)(34-36)(35-49)(36-38)(37-44)(37-55)(38-50)(39-43)(39-60)(40-46)(40-52)(41-47)(42-47)(42-56)(43-55)(44-56)(45-48)(45-61)(46-62)(48-54)(49-63)(50-51)(51-63)(52-64)(52-66)(53-56)(53-67)(54-65)(54-69)(55-67)(57-75)(58-76)(59-77)(60-78)(61-80)(62-73)(63-77)(64-65)(64-73)(65-80)(66-69)(66-74)(67-78)(68-70)(68-71)(68-79)(69-79)(70-74)(70-75)(71-76)(71-81)(72-75)(72-76)(72-82)(77-83)(78-83)(79-83)(80-83)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16 | 11 | 6.5 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| A549 | 38 | 17 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
| LO2 | 47 | 34 | 10.1016/j.jinorgbio.2024.11280... | 2025 |
🧬 Cell Death Types (4)
Apoptosis
high
«activation of caspase 3 and Bcl-2 family proteins to induce apoptosis»
Autophagy
high
«8a, 8b and 8c induced autophagy by inhibiting the AKT/PI3K/mTOR signaling pathway, downregulating p62 and promoting Beclin-1 expression upon light irradiation»
Ferroptosis
high
«The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess the potential to induce ferroptosis»
Immunogenic Cell Death
medium
«upregulated the expression of the damage-associated molecules, HMGB1, CRT, and HSP70. The presence of Fer-1 was effective on increasing the cell survival, which demonstrates that the complexes possess...»